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One notable example is orforglipron (LY3502970), a small molecule in Phase III trial, binds to GLP-1R at a distinct site closer to the extracellular side of the transmembrane helical bundle rather than deeply within the orthosteric pocket (Kawai et al., 2020

Different populations have varying needs, necessitating tailored approaches

2022 Jun;39(6):1233-1248

Ramirez-Gomez, V

doi: 10.1210/en.2015-1546

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